Ingenuity

  • Ingenuity Pathway Analysis (IPA) and Advanced Analytics are intuitive web-based applications for quickly analyzing and accurately interpreting the biological meaning in genomic data.
  • The Center for Health Insights manages accounts and schedules access for the UMKC Ingenuity Pathway Analysis (IPA) and Advanced Analytics.
  • The IPA Knowledge Base integrates detailed biological findings from peer-review literature with related data from sources such as RefSeq, OMIM, and ClinVar as well as information on drug compounds and much more. The repository, manually curated for more than a decade and continually improved, offers scientists the ability to find relevant biological connections faster and more reliably than would otherwise be possible.
  • Accelerates research by bringing the biology into the data, simplifying the process, saving time on literature searches, and allowing every single gene of a microarray to be viewed giving researchers insights that might have been overlooked.

Need to Schedule Access?

Fill out the form below to reserve an IPA and Advanced Analytics appointment time. Time is reserved in 3 hour blocks.
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What are Ingenuity Best Practices?

  • Calculate metrics outside of IPA (e..g. fold-change, p-value).
    • Only 1 header row allowed
    • One column must have identifers, perferably the left-most column
      • Best to use numeric identifer
    • 0 to 3 expression value types per observation
    • Can have up to 20 observations
    • IPA will only look at the top worksheet in an worksheet
  • Group related observations into a single spreadsheet if possible.
    • Time course, drug concentration, cell lines, etc.
  • Specify array platform (chip) if possible.
    • It is OK to use “Not specified/applicable”.
  • Pre-filter data at the lowest threshold that you have confidence in.
    • For example, probe measurement p-value of .05 or other criteria.
    • Use the Recalculate button to refresh the screen.